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A combination drug treatment doubled survival time for patients with an aggressive form ofcolorectal cancer, according to late-stage trial data published Friday inThe New England Journal of Medicineand presented at the American Society of Clinical Oncology's annual meeting in Chicago. The three-treatment combination included a standard chemotherapy drug, an antibody drug called cetuximab and a pill from Pfizer called Braftovi, which targets acancer mutation called BRAF V600E. The mutation shows up in about 10% of patients with colorectal cancer, said Dr. Lionel Kankeu Fonkoua, a gastrointestinal oncologist at the Mayo Clinic Comprehensive Cancer Center in Rochester, Minnesota. Patients with the mutation tend to survive for less than a year after diagnosis, and they often don't respond well to standard chemotherapy treatments, said Fonkoua, who wasn't involved with the new trial. According to Pfizer, the risk of death for these patients is more than double compared with those without the mutation. Braftovi was initially approved in 2020 to be used with cetuximab in this group of patients after other treatments had failed. The new trial looked at the drug combination as a so-called first-line therapy. The Food and Drug Administrationgranted the treatment fast-track approval as a first-line approach in Decemberon the condition that Pfizer provide additional data confirming its effectiveness. The agency often grants fast-track approval to treatments that address serious or life-threatening conditions, especially when there's an unmet medical need. Dr. Christopher Lieu, a professor of medicine at the University of Colorado School of Medicine who wasn't involved with the research, called the results "very impactful." "Patients are clearly living longer, and this represents the new standard of care for this specific subset of patients with this specific mutation," Lieu said. The trial included more than 600 patients with the mutation who had metastatic colorectal cancer. Patients were randomized to get either the three-drug combination treatment or standard chemotherapy alone. Some of the patients in the latter group were also given bevacizumab, a first-line treatment for metastatic colorectal cancer. The trial found that patients who got the combination treatment lived, on average, about 30 months, compared with about 15 months for those who got standard chemotherapy, with or without bevacizumab. What's more, 47% of patients who got the combination treatment had no disease progression after two years, meaning their cancer didn't grow or spread. The treatment was well-tolerated, with no unexpected safety concerns that would've caused investigators to stop the trial. "This is a really remarkable finding," said Dr. Scott Kopetz, a professor of gastrointestinal medical oncology at the MD Anderson Cancer Center in Texas and a co-principal investigator in the trial. "When we bring this together with standard of care chemotherapy, we get really substantially prolonged survival for these patients that are really unprecedented for this disease type." More than 141,000 new cases of colorectal cancer are diagnosed in the U.S. each year, making it the fourth most common cancer, according tothe Centers for Disease Control and Prevention. About 52,900 people in the U.S. are expected to die from colorectal cancer this year, according tothe American Cancer Society. Laurie Ritchie, 61, of St. Louis, got the combination treatment in October 2023. Her results weren't included in the clinical trial analysis. Ritchie had been diagnosed with metastatic colorectal cancer with the BRAF mutation — a diagnosis she describes as "a huge shock." Previous colonoscopies hadn't detected cancer; by the time she was diagnosed, the cancer had already reached Stage 4. It eventually spread to her lungs and ovaries. Since she got the combination treatment, she said her blood tests have consistently shown no trace of cancer. While she still worries about the cancer coming back, she says she's now focused on living fully — including going water skiing and downhill skiing. "I've kind of learned to think of it as something in the trunk, not in the front seat," she said. "It still feels a bit like a ticking time bomb inside me, but I think the work I've done on my mental health has really helped me live with it."

Tropical Storm Alvinis producing large swells that will affect portions of the coasts of west-central and southwestern Mexico and the southern Baja California peninsula in the next couple of days, according to theNational Hurricane Center. These swells are "likely to cause life-threatening surf and rip current conditions" and the hurricane center advises people to keep an eye on weather forecasts from their local weather office. TheNHC said Friday morningthe storm is located about 445 miles south-southeast of the southern tip of the Baja California peninsula with maximum sustained winds of about 50 mph with higher gusts. Alvin is moving toward the north-northwest, however a turn toward the north is expected Friday. "Gradual weakening is forecast during the next couple of days, and Alvin is expected to degenerate to a remnant low on Saturday," according to the hurricane center. While the 2025 Pacific hurricane season began on May 15, the Atlantic season officially begins on June 1 and will last through the end of November. Active hurricane weather typically peaks between mid-August and mid-October. TheNational Oceanic and Atmospheric Administrationreleased its prediction for the 2025 Atlantic hurricane season on Thursday, May 22,predicting an above-average season, with 13 to 19 named storms and six to 10 hurricanes. The hurricane center is also keeping tabs on a disturbance just offshore of Central America and southern Mexico. The NHC said an area of low pressure could form by the middle part of next week and that environmental conditions appear "favorable for some development" while it moves generally westward to west-northwestward. The hurricane center gives the disturbance a 20% chance of formation through the next seven days. This forecast track shows the most likely path of the center of the storm. It does not illustrate the full width of the storm or its impacts, and the center of the storm is likely to travel outside the cone up to 33% of the time. Illustrations include an array of forecast tools and models, and not all are created equal. The hurricane center uses only the top four or five highest-performing models to help make its forecasts. Hurricanes are born in the tropics, above warm water. Clusters of thunderstorms can develop over the ocean when water temperatures exceed 80 degrees Fahrenheit. If conditions are right, the clusters swirl into a storm known as a tropical wave or tropical depression. A tropical depression becomes a named tropical storm once its sustained wind speeds reaches 39 miles per hour. When its winds reach 74 mph, the storm officially becomes a hurricane. Delaying potentially life-saving preparations could mean waiting until it's too late. "Get your disaster supplies while the shelves are still stocked, and get that insurance checkup early, as flood insurance requires a 30-day waiting period," NOAA recommends. Prepare now for hurricanes:Here's what you should do to stay safe before a storm arrives Develop an evacuation plan: If you are at risk from hurricanes, you need anevacuation plan. Now is the time to begin planning where you would go and how you would get there. Assemble disaster supplies: Whether you're evacuating or sheltering-in-place, you're going to need supplies not just to get through the storm but for the potentially lengthy aftermath,NOAA said. Get an insurance checkup and document your possessions: Contact your insurance company or agent now and ask for aninsurance check-upto make sure you have enough insurance to repair or even replace your home and/or belongings. Remember, home and renters insurance doesn't cover flooding, so you'll need a separate policy for it. Flood insurance is available through your company, agent, or theNational Flood Insurance Program. Act now, as flood insurance requires a 30-day waiting period. Create a family communication plan: NOAA said to take the time now to write down yourhurricane plan, and share it with your family. Determine family meeting places, and make sure to include an out-of-town location in case of evacuation. Strengthen your home: Now is the time to improve your home's ability to withstand hurricane impacts. Trim trees; install storm shutters, accordion shutters, and/or impact glass; seal outside wall openings. Gabe Hauari is a national trending news reporter at USA TODAY. You can follow him on X@GabeHauarior email him at Gdhauari@gannett.com. This article originally appeared on USA TODAY:Tropical Storm Alvin tracker: See projected path, spaghetti models

WASHINGTON (Reuters) -U.S. President Donald Trump on Friday said China had violated an agreement on tariffs with the United States. "China, perhaps not surprisingly to some, HAS TOTALLY VIOLATED ITS AGREEMENT WITH US. So much for being Mr. NICE GUY!," Trump said in a post on Truth Social. (Reporting by Susan Heavey, Katharine Jackson)

Wildfire smoke is pouring into the Midwest from Canada as dozens of fires burn north of the border. Let's get you caught up on all the latest information: Since the upper Midwest is closest to the fires burning in Saskatchewan and Manitoba, upper-level winds are blowing the thick smoke southward. This has prompted air quality alerts for the entire state of Wisconsin on Friday, as well as parts of Michigan's Upper Peninsula and northern Minnesota. (MORE:Here's What Wildfire Smoke Does To Your Body) Chicago residents could also experience degraded air quality as the smoke pushes southward. From weather.com senior digital meteorologistChris Dolce: The image below shows near-surface smoke on Saturday afternoon – this is the kind of smoke that can be unhealthy to breathe since it's at the lower levels. As you can see, the greatest concentrations of that will be in the Midwest and Northern Plains today through this weekend. However, some of it is modeled in a less concentrated fashion into the South and East this weekend: This animation shows that a much larger area will see smoke aloft that is not necessarily an air quality concern, but will lead to hazy skies and orange/red sunrises and sunsets. That is spreading into the Midwest now and will head into the South and East this weekend. As you can see, this is amuchlarger area, but areas that overlap with near-surface smoke have the greatest air quality concerns in the Midwest and Northern Plains: - Make sure you have the latest version ofThe Weather Channel app– if you don't, head to your phone's app store and download/update it. - Locate the pill that displays lifestyle options like "Allergies," "Cold & Flu" and "Skin Health." Locate the button that says "Breathing" and tap on it to load our Breathing module. - Scroll down to "Today's Biggest Impacts" and the air quality index will load. You'll also find other important information in that module. Some 17,000 residents in Manitoba remain under evacuation orders as wildfires have spread in the province,and also into Saskatchewan, BBC.com reported. "The conditions that our northern residents, communities and wildland firefighters are facing today are as severe or quite likely unlike anything we have faced in quite some time, if not ever," Scott Moe, Premier of Saskatchewan, told BBC.com. A state of emergency is in effect in Manitoba and more than 80 fires have been deemed "out of control" in Canada. The entire town of Flin Flon, Manitoba, was ordered to evacuate; about 5,000 people live in the city. As the fires grew, some residents in Saskatchewan have also been ordered to evacuate their homes. According to the Associated Press: "Canada's wildfire season runs May through September. Its worst-ever wildfire season was in 2023. It choked much of North America with dangerous smoke for months."

Six more space touristsare preparing to join the growing ranks of civilianswho have flown on a Blue Origin rocket to the edge of space. The vehicle they'll ride to orbit, Blue Origin's New Shepard, is the same one that58 others have ridden to spaceon 11previous human spaceflightsfrom the company's west Texas facility. The New Shepard's maiden voyage in July 2021 with a creweven included billionaire Amazon founder Jeff Bezos, who also owns the space technology company. New Shepard is composed of both a rocket and a crew capsule, which is outfitted with large windows for its passengers to glimpse spectacular views thatmost of us will never see. The rest of us will instead have to content ourselves with watching the mission on solid ground. Fortunately, Blue Origin will provide a livestream for the launch and spaceflight. Here'severything to know aboutBlue Origin's next human spaceflight and how to watch a livestream. When is the next Blue Origin launch?What to know about New Shepard liftoff, crew Billionaire Jeff Bezos, best known for founding Amazon, is the founder of the private space technology company Blue Origin. Bezos himself even boarded Blue Origin's New Shepardfor its maiden crewed voyage in July 2021, which came after the spacecraft flew on 15 flight tests beginning in 2012. For nearly four years since its first crewed mission, the New Shepard spacecraft has served as a powerful symbol of Blue Origin's commercial spaceflight ambitions amida growing space tourism industry. In addition to sending space tourists on brief joy rides to the edge of space, Blue Origin has also increasingly sought to compete with Elon Musk's SpaceX. Blue Origin's massive New Glenn rocket, whichflew on its inaugural flight test in January, is also being developed for future spaceflights. At 320 feet tall, the spacecraft rivalsSpaceX's 400-foot Starshipin size. Blue Origin's next crewed launch, known as NS-32, could get off the ground as early as 9:30 a.m. ET (8:30 a.m. CT) Saturday, May 31, the company announced announced Tuesday, May 27. Blue Origin New Shepard rocket launches take place from the company's private ranch facility known asLaunch Site One. The facility is located 30 miles north of the town of Van Horn in Culberson County – more than 140 miles east of El Paso near the U.S.-Mexico border. Blue Origin will provide a webcast of the launch beginning about 30 minutes ahead of the scheduled liftoff on itswebsite. When the New Shepard gets off the ground again, the six people selected to board it will join58 others who have flownon the spacecraft across 11 previous human spaceflights. Here's a look at the passengers: Aymette (Amy) Medina Jorge, a STEM teacher at Odyssey Academy in Galveston, Texas, who has led more than 60 zero-gravity space experiments. Gretchen Green, a radiologist specializing in women's imaging with more than 20 years of clinical experience. Jaime Alemán, a Panamanian attorney, businessman and former ambassador to the United States. Jesse Williams, a Canadian entrepreneur and adventurer who serves as CEO of Car History Group, which he founded in 2012. Mark Rocket, an entrepreneur from Christchurch, New Zealand, who is CEO of Kea Aerospace, which develops solar-powered UAVs for aerial imaging and monitoring, and president of Aerospace New Zealand. Paul Jeris, a real estate developer and entrepreneur Eachspaceflight on a New Shepard vehiclelasts about 11 minutes from liftoff to capsule touchdown. Named after astronaut Alan Shepard, the first American in space, the 60-foot-tall New Shepard rocket is topped withthe gum drop-shaped crew capsule. During its ascent, the spacecraft reaches supersonic speeds surpassing 2,000 mph before the rocket booster separates from the crew capsule. At that point, those aboard the capsule become weightless as the spacecraft continues toward its highest point on its brief voyage above the Kármán Line – the 62-mile-high internationally recognized boundary of space. While experiencing a few minutes of microgravity, passengers have the opportunity to unstrap themselves from their seats to gaze out thecapsule's large windowsand take in a stunning view of Earth. Meanwhile, the rocket booster heads back to the ground while firing its engines and using its fins to slow and control its descent to land vertical about two miles from the launchpad. The capsule itself eventually begins what Blue Origin refers to as a "stable freefall" – plummeting back to Earth as three massive parachutes deploy and the capsule makes a soft landing in the desert, sending up plumes of dust. Eric Lagatta is the Space Connect reporter for the USA TODAY Network. Reach him at elagatta@gannett.com This article originally appeared on USA TODAY:Blue Origin launch: Date, time, how to watch crewed mission live