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Wildfire smoke is pouring into the Midwest from Canada as dozens of fires burn north of the border. Let's get you caught up on all the latest information: Since the upper Midwest is closest to the fires burning in Saskatchewan and Manitoba, upper-level winds are blowing the thick smoke southward. This has prompted air quality alerts for the entire state of Wisconsin on Friday, as well as parts of Michigan's Upper Peninsula and northern Minnesota. (MORE:Here's What Wildfire Smoke Does To Your Body) Chicago residents could also experience degraded air quality as the smoke pushes southward. From weather.com senior digital meteorologistChris Dolce: The image below shows near-surface smoke on Saturday afternoon – this is the kind of smoke that can be unhealthy to breathe since it's at the lower levels. As you can see, the greatest concentrations of that will be in the Midwest and Northern Plains today through this weekend. However, some of it is modeled in a less concentrated fashion into the South and East this weekend: This animation shows that a much larger area will see smoke aloft that is not necessarily an air quality concern, but will lead to hazy skies and orange/red sunrises and sunsets. That is spreading into the Midwest now and will head into the South and East this weekend. As you can see, this is amuchlarger area, but areas that overlap with near-surface smoke have the greatest air quality concerns in the Midwest and Northern Plains: - Make sure you have the latest version ofThe Weather Channel app– if you don't, head to your phone's app store and download/update it. - Locate the pill that displays lifestyle options like "Allergies," "Cold & Flu" and "Skin Health." Locate the button that says "Breathing" and tap on it to load our Breathing module. - Scroll down to "Today's Biggest Impacts" and the air quality index will load. You'll also find other important information in that module. Some 17,000 residents in Manitoba remain under evacuation orders as wildfires have spread in the province,and also into Saskatchewan, BBC.com reported. "The conditions that our northern residents, communities and wildland firefighters are facing today are as severe or quite likely unlike anything we have faced in quite some time, if not ever," Scott Moe, Premier of Saskatchewan, told BBC.com. A state of emergency is in effect in Manitoba and more than 80 fires have been deemed "out of control" in Canada. The entire town of Flin Flon, Manitoba, was ordered to evacuate; about 5,000 people live in the city. As the fires grew, some residents in Saskatchewan have also been ordered to evacuate their homes. According to the Associated Press: "Canada's wildfire season runs May through September. Its worst-ever wildfire season was in 2023. It choked much of North America with dangerous smoke for months."

Six more space touristsare preparing to join the growing ranks of civilianswho have flown on a Blue Origin rocket to the edge of space. The vehicle they'll ride to orbit, Blue Origin's New Shepard, is the same one that58 others have ridden to spaceon 11previous human spaceflightsfrom the company's west Texas facility. The New Shepard's maiden voyage in July 2021 with a creweven included billionaire Amazon founder Jeff Bezos, who also owns the space technology company. New Shepard is composed of both a rocket and a crew capsule, which is outfitted with large windows for its passengers to glimpse spectacular views thatmost of us will never see. The rest of us will instead have to content ourselves with watching the mission on solid ground. Fortunately, Blue Origin will provide a livestream for the launch and spaceflight. Here'severything to know aboutBlue Origin's next human spaceflight and how to watch a livestream. When is the next Blue Origin launch?What to know about New Shepard liftoff, crew Billionaire Jeff Bezos, best known for founding Amazon, is the founder of the private space technology company Blue Origin. Bezos himself even boarded Blue Origin's New Shepardfor its maiden crewed voyage in July 2021, which came after the spacecraft flew on 15 flight tests beginning in 2012. For nearly four years since its first crewed mission, the New Shepard spacecraft has served as a powerful symbol of Blue Origin's commercial spaceflight ambitions amida growing space tourism industry. In addition to sending space tourists on brief joy rides to the edge of space, Blue Origin has also increasingly sought to compete with Elon Musk's SpaceX. Blue Origin's massive New Glenn rocket, whichflew on its inaugural flight test in January, is also being developed for future spaceflights. At 320 feet tall, the spacecraft rivalsSpaceX's 400-foot Starshipin size. Blue Origin's next crewed launch, known as NS-32, could get off the ground as early as 9:30 a.m. ET (8:30 a.m. CT) Saturday, May 31, the company announced announced Tuesday, May 27. Blue Origin New Shepard rocket launches take place from the company's private ranch facility known asLaunch Site One. The facility is located 30 miles north of the town of Van Horn in Culberson County – more than 140 miles east of El Paso near the U.S.-Mexico border. Blue Origin will provide a webcast of the launch beginning about 30 minutes ahead of the scheduled liftoff on itswebsite. When the New Shepard gets off the ground again, the six people selected to board it will join58 others who have flownon the spacecraft across 11 previous human spaceflights. Here's a look at the passengers: Aymette (Amy) Medina Jorge, a STEM teacher at Odyssey Academy in Galveston, Texas, who has led more than 60 zero-gravity space experiments. Gretchen Green, a radiologist specializing in women's imaging with more than 20 years of clinical experience. Jaime Alemán, a Panamanian attorney, businessman and former ambassador to the United States. Jesse Williams, a Canadian entrepreneur and adventurer who serves as CEO of Car History Group, which he founded in 2012. Mark Rocket, an entrepreneur from Christchurch, New Zealand, who is CEO of Kea Aerospace, which develops solar-powered UAVs for aerial imaging and monitoring, and president of Aerospace New Zealand. Paul Jeris, a real estate developer and entrepreneur Eachspaceflight on a New Shepard vehiclelasts about 11 minutes from liftoff to capsule touchdown. Named after astronaut Alan Shepard, the first American in space, the 60-foot-tall New Shepard rocket is topped withthe gum drop-shaped crew capsule. During its ascent, the spacecraft reaches supersonic speeds surpassing 2,000 mph before the rocket booster separates from the crew capsule. At that point, those aboard the capsule become weightless as the spacecraft continues toward its highest point on its brief voyage above the Kármán Line – the 62-mile-high internationally recognized boundary of space. While experiencing a few minutes of microgravity, passengers have the opportunity to unstrap themselves from their seats to gaze out thecapsule's large windowsand take in a stunning view of Earth. Meanwhile, the rocket booster heads back to the ground while firing its engines and using its fins to slow and control its descent to land vertical about two miles from the launchpad. The capsule itself eventually begins what Blue Origin refers to as a "stable freefall" – plummeting back to Earth as three massive parachutes deploy and the capsule makes a soft landing in the desert, sending up plumes of dust. Eric Lagatta is the Space Connect reporter for the USA TODAY Network. Reach him at elagatta@gannett.com This article originally appeared on USA TODAY:Blue Origin launch: Date, time, how to watch crewed mission live

Israeli airstrikes killed at least 14 people in the Gaza Strip, hospital officials said Friday, while Hamas was reviewing a new Israeli-approved ceasefire proposal after giving it an initial cool response. President Donald Trump's Mideast envoy had expressed optimism this week aboutbrokering an agreementthat could halt the Israel-Hamas war, allow more aid into Gaza, and return more of the 58 hostages still held by Hamas, around a third of whom are alive. Experts say a nearly three-month Israeli blockade of Gaza —slightly eased in recent days— has pushed the population of roughly 2 million Palestiniansto the brink of famine. Israel's war in Gaza has killed around 54,000 Palestinians, mostlywomen and children, according to the Gaza Health Ministry, which does not distinguish between civilians and combatants in its tally. The war began with Hamas' Oct. 7, 2023, attack on Israel, which left around 1,200 dead. Here's the latest: At least 14 dead in Gaza strikes, medics say Hospital officials and paramedics say Israeli airstrikes on the Gaza Strip have killed at least 14 people and wounded others. Officials at Shifa Hospital in northern Gaza said the bodies of 12 people, including three women, were brought Friday from the nearby Jabaliya refugee camp. The Palestinian Red Crescent Society said the bodies of two people as well as nine others who were wounded were taken to Al-Quds Hospital in Gaza City. It said one of the wounded is a doctor who works at the same hospital. Hamas reviewing a new ceasefire proposal Hamas said Friday it was reviewing a new Israeli-approved ceasefire proposal. The White House said Thursday that Israel accepted a new U.S. proposal for a temporary ceasefire with Hamas. Hamas officials, however, gave the draft a cool response, saying that it seeks to perpetuate Israel's policies of killing and starving people in Gaza. Still, the group said it was going to thoroughly review it. Israeli Prime Minister Benjamin Netanyahu has refused to end the war until all the hostages are released and Hamas is either destroyed or disarmed and sent into exile. Hamas has said it will only release the remaining hostages for a lasting ceasefire and a full Israeli withdrawal. Netanyahu undergoes a routine colonoscopy Israeli Prime Minister Benjamin Netanyahu underwent a routine colonoscopy on Friday morning in Jerusalem, his office said. The office did not provide further information about whether Netanyahu was moderately sedated or under general anesthesia for the procedure. Netanyahu, 75, underwentsuccessful surgery in Decemberto have his prostate removed. Netanyahu has gone to great lengths to bolster a public image of himself as a healthy, energetic leader, as he manages multiple crises including thewar in Gazaand histrial for alleged corruption, despite a series of recent health setbacks.

Massive wildfires burning out of control in western and central Canada are forcing thousands to flee as dire forecasts for the country's fire season come to fruition. The intensifying blazes are also beginning to send hazardous smoke toward major cities in the United States. The premiers of Manitoba and Saskatchewan have declared states of emergency and much of Canada, from the Northwest Territories and Alberta to Quebec, are at "extreme" risk of wildfires on Thursday—the highest level onEnvironment Canada's fire risk scale. There are just over 160 wildfires burning across Canada as of Thursday, according to the Canadian Interagency Forest Fire Center, and about half are uncontrolled. The country raised itsNational Preparedness Levelto level 5 of 5 on Thursday, which is unusually high for this early in the fire season. Last year, Canada didn't reach that level until July 15. In Manitoba, around 17,000 people are under evacuation orders, including the city of Flin Flon, Pimicikamak Cree Nation and the northern community of Cross Lake, along with Mathias Colomb Cree Nation, according to CNN's Canadian news partnerCBC News. The province's state of emergency will remain in effect for a month and may be extended if conditions warrant, said Manitoba Premier Wab Kinew. "This is a moment of fear and uncertainty. This is a moment of concern," Kinew said, acknowledging this is the largest evacuation order in "in most people's living memory." "But I want to tell you that your fellow Manitobans will welcome you. We will get through this difficult period, and we'll get through this trying period the way that we always do: by working together." Wildfires have forced thousands of evacuations in neighboring Saskatchewan as well, CBC reported, and Saskatchewan Premier Scott Moedeclared a 30-day provincial emergencyThursday. It followed calls from First Nations leaders to take that step, noting "deep concerns" over resources to battle the fires. "It's a very serious situation that we're faced with in Saskatchewan. We do need some rainfall and we need that sooner rather than later," Moe said at a news conference. Climate change is leading to anincrease in wildfire risk days, as well as more frequent andlarger firesthat exhibitmore extreme wildfire behavior. Canada had its worst wildfire season on record in 2023, when extreme heat and drought helped propel blazes thatburned more than 45 million acres. Last year's fire season was Canada's second-worst of the century. Some of those blazes also sent thick, hazardous smoke into US cities. This year, wildfires have burned more than 1.58 million acres in Canada so far, about 40% above the 10-year average for this point in the year. Nearly 90% of the acreage burned has been in Saskatchewan and Manitoba, though there are many ongoing blazes in British Columbia and Alberta as well, where some evacuations are underway. Fires this year have burned 490,000 acres burned in Manitoba, which is about four times the average for this time of year, according to theCanadian Interagency Forest Fire Center. Computer models show that smoke from the western Canadian blazes will reach the Upper Midwest and Great Lakes Thursday and Friday, potentially affecting the cities of Green Bay, Wisconsin, Milwaukee, Chicago and Detroit. The smoke will likely be in the lower to middle levels of the atmosphere, which could lower visibility and crater air quality in some areas. Authorities in Minnesota have already issued anair quality alertbeginning Thursday for northeastern parts of the state, warning that fine particle levels are expected to reach "a level considered unhealthy for everyone." A similar alert is in effect in northern Michigan for Friday. Some of the mid-and-low-level smoke could linger through the weekend in parts of the Midwest, according to the National Weather Service, while projections show a high-level smoke plume plunging even further south across the Plains. High-level smoke – which doesn't affect air quality – is beginning to spread across the Northern Plains, shielding the sun slightly and potentially creating vibrant sunrises and sunsets. More smoky days could be ahead for millions this summer. Canada'sseasonal wildfire forecastcalled for well above-average blazes, and much of the western US, too, will have above-normal wildfire potential by July, according to National Interagency Fire Centerforecasts. CNN Meteorologist Brandon Miller contributed to this report. For more CNN news and newsletters create an account atCNN.com

By Julie Steenhuysen and Deena Beasley (Reuters) -Gilead Sciences says it still plans to supply its twice-yearly injection for preventing HIV infection in low-income countries if it wins U.S. approval despite funding uncertainty over the Trump Administration's pullback in aid spending. Some AIDS experts, including activists and doctors, say the Gilead drug, lenacapavir, could help end the 44-year-old epidemic that infects 1.3 million people a year and is estimated by the World Health Organization to have killed more than 42 million. An FDA approval decision is expected by June 19 for lenacapavir, which proved to be nearly 100% effective at preventing HIV in large trials. If the Food and Drug Administration green lights the drug, and its view is seconded by the WHO, the shots could start to roll out early in 2026 to at least 2 million people in 18 low-income countries based on Gilead's agreement with the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund, a worldwide partnership targeting HIV, tuberculosis and malaria. Gilead agreed to provide lenacapavir at cost for two-to-three years while six generic drugmakers, which were granted licenses to make the medicine for low-income countries, ramp up production. Experts said a successful launch of a long-acting HIV prevention drug could help stall the epidemic. Until recently, the only pre-exposure prophylaxis (PrEP) options for people at high risk of infection were daily pills, requiring careful adherence to be effective. "You can foresee a day where there are no new HIV diagnoses. It doesn't happen if we only do this in the U.S.," Gilead Chief Commercial Officer Johanna Mercier said. "We need to make sure we have a global approach to this launch." PEPFAR being part of the effort is Gilead's intent and goal, Mercier said. "Unfortunately, if they're not part of that mix, our goal is still to meet that objective of 2 million people getting access." Wall Street has a close eye on lenacapavir, one of the highest-profile drugs to undergo FDA review since President Donald Trump named Robert F. Kennedy Jr. as health secretary and promised to upend the status quo. Most of the drug's profits are expected in the U.S., with annual sales reaching $1 billion by next year, according to analysts' estimates compiled by LSEG. 'INCREDIBLE DISMAY' Whether all of the agreed funding for low-income countries - most of which are in Africa - will come through is unclear. Countries that rely on aid are already reeling from funding cuts by the Trump Administration, including to PEPFAR, and AIDS researchers are bracing for the worst. The United Nations program on HIV/AIDS earlier this month said many HIV prevention programs supported by PEPFAR were stalled, although services for pregnant and breastfeeding women were technically exempt from the cuts. Peter Sands, executive director of the Global Fund, told Reuters the group intends to fund as much of the lenacapavir rollout as possible, but it will need to start slowly. "It's not just the uncertainty over PEPFAR's funding that's an issue, but the uncertainty over our funding," Sands said, adding that the group's first priority is treating people already infected with the deadly virus. Much will depend on the success of the Global Fund's effort to raise $18 billion to fund its work from 2027-2029. The U.S. is its largest donor, committing $6 billion in the previous funding round. It is unclear what the U.S. may provide this round, or whether other big governments will step up. UNAIDS estimates that the permanent discontinuation of HIV prevention and treatment programs supported by PEPFAR would lead to an additional 6.6 million new HIV infections between 2025 and 2029. The U.S. State Department, which oversees PEPFAR, did not respond to a request for comment. Gilead declined to comment on its manufacturing cost for lenacapavir, whose U.S. price is likely to be on par with current preventive medications at around $25,000 per year. ViiV Healthcare's Apretude, an injection given every two months, costs about 124.20 pounds ($168) in low- and middle-income countries. Mitchell Warren, executive director of the AIDS nonprofit AVAC, estimates the eventual annual cost at $100-$120. The lower the price, the more people who could receive it, he said. Warren said PEPFAR could still participate, and others may come forward. The Gates Foundation and the Children's Investment Fund Foundation are "actively involved in all of these conversations," he said, as is the Elton John AIDS Foundation. Linda-Gail Bekker of the University of Cape Town, who led lenacapavir clinical trials in South Africa and Uganda, said she was elated when she first saw the findings. "The huge feeling I have now is one of incredible dismay," said Bekker of uncertainty over the Trump administration's commitment to PEPFAR and HIV prevention in poor nations. "It felt like the stars were aligning, and one of the stars has fallen out of the sky." (Reporting by Julie Steenhuysen in Chicago and Deena Beasley in Los Angeles; additional reporting by Jennifer Rigby in London; editing by Caroline Humer and Bill Berkrot)